Three brothers and one sister, parents not known. According to Trapp[113],
they were cousins of Emperor Manuel II.
1. IOANNES Asanes (-Eubœa 20 Jun 1386). Archon at Constantinople 1371. Arrested. He became a teacher on Eubœa. m ---, sister of --- Laskaris Palaiologos, daughter of ---. The primary source which confirms her parentage and marriage has not yet been identified. Ioannes Asanes & his wife had two children:
a) HELENE Asanina Palaiologina. The primary source which confirms her parentage and marriage has not yet been identified. [1400]. m MANUEL Raoul Melikes. In Morea 1439/40.

daughter.
2. KONSTANTINOS Asanes (-[1415]). In Italy 1369/1370. Melograph 1385/1415. Senator 1409.
3. son.
4. THEODORA Asanina (-1/21 May 1398). The primary source which confirms her parentage and marriage has not yet been identified. m BARTOLOMEO [III] Ghisi Lord of 1/3 Negroponte, Eubœa, Tinos and Mykonos, son of GIORGIO [II] Ghisi & his wife Simona d'Aragón (-[18 Sep 1383/24 Jul 1390]). Marshall of the Principality of Achaia. He was appointed member of the High Council of the Republic of Venice in 1383, in compensation for Venice having bought the suzerainty over Eubœa from Jacques des Baux titular Emperor of Constantinople[114].
The relationship between the following family groups and the other members of this family is unknown:
1. ISAAKIOS Asanes . 1400. m ---. The name of Isaakios's wife is not known. Isaakios & his wife had one child:
a) --- Asanina . The primary source which confirms her parentage and marriage has not yet been identified. m GEORGIOS Doukas Philanthropenos, son of --- (-1452).
2.DEMETRIOS Asanes. Governor of Corinth 1444. Governor of Muchlion in the Peloponese 1456/58, which he surrendered to the Turks. Georgios Phrantzes records that "Demetrius Asanes" surrendered "Mochlium" to the Ottomans in 1458[115]. m ---. The name of Demetrios's wife is not known. Demetrios Asanes & his wife had six children:
a) son.

daughter.
c) IOANNES Asanes . On Rhodos.
d) THOMAS Asanes (bur Naples).
e) ALEXIOS Asanes (-killed in battle against the Turks).
f) MARIA Asanina (-after 1460). The primary source which confirms her parentage and marriage has not yet been identified. After the death of her husband, she was taken to Constantinople where she was courted by Georgios Amiroutzes, former minister of David Komnenos Emperor in Trebizond whom he had betrayed, who "dropped down dead, a dice-box in his hand"[116]. m firstly FRANCO Acciaiuoli, son of ANTONIO [II] Acciaiuoli & his wife Maria Giorgi (-murdered 1460). m secondly (bigamously 1463) GEORGIOS Amiroutzes (-Constantinople after 1469). Philosopher and Theologist. Protobestiarios in Trebizond [1458]/61, megas logothetes. He took part in the council of Florence. He was the teacher of Sultan Mohammed II in 1461.
3. MANUEL Laskaris Palaiologos Asanes. Governor of Imbros [1438/39]-1444.
4. MARIA Palaiologina Tsamplakinissa Asanina (-in Trebizond after 1447). The primary source which confirms her parentage and marriage has not yet been identified. m ([1440/46]) IOANNES Gabras Prince of Gothia, son of ALEXIOS Gabras Prince of Gothia & his wife --- (-in Trebizond after 1447).
5. ALEXANDROS Asanes. The Pope promised him help to retake Imbros in 1458/59.
6. PAULOS Asanes. Ambassador to Sultan Murad II 1437. Governor of Constantinople 1438/40. He fled with his daughters to the Peloponese 1441. m ---. The name of Paulos's wife is not known. Paulos Asanes & his wife had three children:
a) MATTHAIOS Palaiologos Asanes (-29 Mar 1467). On Lemnos and in Morea 1449. He defeated the Turks at Leontarion in 1452. Governor of Corinth 1454/58, which he surrendered to the Turks. Georgios Phrantzes records that "duces fortissimo, Matthaeus Asanes, frater uxoris Demetrii despotæ, filius Pauli Asanis…et Nicephorus Lucanes" surrendered to the Ottomans in 1458[117]. He was in the service of the Turks in 1458, holding the salt monopoly. He was banished to Didymoteichon for fraud. m --- Eudaimonoioanne, daughter of GEORGIOS Eudaimonoioannes, mesaxon in Morea & his wife ---. The primary source which confirms her parentage and marriage has not yet been identified. Matthaios & his wife had one child:
i) daughter . The primary source which confirms her parentage has not yet been identified.

THEODORA Asanina (-[1470/71]). Her origin is confirmed by Georgios Phrantzes who names "Matthaeus Asanes, frater uxoris Demetrii despotæ, filius Pauli Asanis"[118]. Georgios Phrantzes records the death in autumn "anni 6979" of "Demetrius despota Adrianopoli…monachus David appellatus" and "eiusdem uxor, regina, non multo post"[119]. m (Jun 1441) as his second wife, DEMETRIOS Palaiologos, despot, Governor of Selymbria, son of Emperor MANUEL II & his wife Jelena Dragaš of Serbia ([1407/08]-Adrianople 1470).
c) SIMONIS Palaiologina Asanina. The primary source which confirms her parentage has not yet been identified. She was a nun as SYMPHROSYNE in 1452/62.